本病由(you)慢(man)性(xing)(xing)(xing)廣(guang)泛性(xing)(xing)(xing)肺-胸疾病發(fa)展而(er)來,呼吸和循環(huan)系統的癥狀常混雜出現,不判定心(xin)臟病是否已(yi)出現,故早(zao)期診斷比(bi)較(jiao)困難。一般認為凡有慢(man)性(xing)(xing)(xing)廣(guang)泛性(xing)(xing)(xing)肺、胸疾病患者,一旦發(fa)現有肺動脈(mo)高壓、右(you)心(xin)室增大而(er)同(tong)時排除了引起(qi)右(you)心(xin)室增大的其他(ta)心(xin)臟病可(ke)能時,即(ji)可(ke)診斷為本病。
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血液檢查:紅(hong)細胞計數和(he)(he)血(xue)(xue)(xue)紅(hong)蛋白(bai)常(chang)增高(gao),紅(hong)細胞壓積正常(chang)或(huo)偏(pian)高(gao),全血(xue)(xue)(xue)粘度、血(xue)(xue)(xue)漿(jiang)(jiang)粘度和(he)(he)血(xue)(xue)(xue)小板聚集率常(chang)增高(gao),紅(hong)細胞電(dian)泳時(shi)間延長,血(xue)(xue)(xue)沉(chen)一般(ban)偏(pian)快;動(dong)脈血(xue)(xue)(xue)氧飽和(he)(he)度常(chang)低于(yu)正常(chang),二氧化碳分壓高(gao)于(yu)正常(chang),呼吸衰竭時(shi)更為顯著(zhu)。在心力(li)衰竭期,可有丙氨酸氨基(ji)轉移(yi)酶和(he)(he)血(xue)(xue)(xue)漿(jiang)(jiang)尿素氮、肌(ji)酐(gan)、血(xue)(xue)(xue)及尿β2微球蛋白(bai)(β2-M)、血(xue)(xue)(xue)漿(jiang)(jiang)腎素活性(PRA)、血(xue)(xue)(xue)漿(jiang)(jiang)血(xue)(xue)(xue)管(guan)緊張素Ⅱ等(deng)含量增高(gao)等(deng)肝腎功能受(shou)損(sun)表現。合并呼吸道感染(ran)時(shi),可有白(bai)細胞計數增高(gao)。在呼吸衰竭不同(tong)階段可出現高(gao)鉀、低鈉、低鉀或(huo)低氯、低鈣、低鎂等(deng)變化。
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痰細菌培養:以甲型鏈(lian)(lian)球(qiu)菌(jun)(jun)(jun)、流感(gan)桿(gan)菌(jun)(jun)(jun)、肺炎球(qiu)菌(jun)(jun)(jun)、葡萄球(qiu)菌(jun)(jun)(jun)、奈瑟(se)球(qiu)菌(jun)(jun)(jun),草(cao)綠(lv)色鏈(lian)(lian)球(qiu)菌(jun)(jun)(jun)等多見,近年(nian)來革蘭陰性桿(gan)菌(jun)(jun)(jun)增多,如綠(lv)膿桿(gan)菌(jun)(jun)(jun)、大(da)腸桿(gan)菌(jun)(jun)(jun)等。
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X線檢查:
1、肺(fei)部變化:隨病因而異,肺(fei)氣腫最(zui)常見(jian)。
2、肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)高(gao)壓表(biao)現:肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)總干(gan)(gan)弧突出,肺(fei)(fei)門(men)部肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)擴(kuo)大延長(chang)及(ji)肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)第一(yi)分支(zhi)。一(yi)般認(ren)為右肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)第一(yi)下(xia)分支(zhi)橫(heng)徑(jing)(jing)≥15mm,或右下(xia)肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)橫(heng)徑(jing)(jing)與氣管(guan)橫(heng)徑(jing)(jing)比(bi)值≥1.07,或動(dong)(dong)(dong)態觀(guan)察較(jiao)原右肺(fei)(fei)下(xia)動(dong)(dong)(dong)脈(mo)(mo)干(gan)(gan)增寬(kuan)2mm以上,可認(ren)為有該支(zhi)擴(kuo)張(zhang)。肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)高(gao)壓顯著時(shi),中心肺(fei)(fei)動(dong)(dong)(dong)脈(mo)(mo)擴(kuo)張(zhang),搏動(dong)(dong)(dong)增強而(er)外(wai)周(zhou)動(dong)(dong)(dong)脈(mo)(mo)驟然變細呈截斷或鼠尾狀。
③心(xin)(xin)(xin)(xin)(xin)臟(zang)變(bian)化:心(xin)(xin)(xin)(xin)(xin)臟(zang)呈(cheng)垂直位,故早期心(xin)(xin)(xin)(xin)(xin)臟(zang)都不(bu)見增(zeng)(zeng)大(da)。右心(xin)(xin)(xin)(xin)(xin)室(shi)流出(chu)道增(zeng)(zeng)大(da)時(shi),表現(xian)為(wei)肺動脈圓錐(zhui)部顯(xian)著凸(tu)出(chu)。此后(hou)右心(xin)(xin)(xin)(xin)(xin)室(shi)流入道也肥厚(hou)增(zeng)(zeng)大(da),心(xin)(xin)(xin)(xin)(xin)尖上(shang)翹。有時(shi)還可見右心(xin)(xin)(xin)(xin)(xin)房擴大(da)。心(xin)(xin)(xin)(xin)(xin)力衰(shuai)竭(jie)時(shi)可有全(quan)心(xin)(xin)(xin)(xin)(xin)擴大(da),但在(zai)心(xin)(xin)(xin)(xin)(xin)力衰(shuai)竭(jie)控(kong)制后(hou),心(xin)(xin)(xin)(xin)(xin)臟(zang)可恢復到原來大(da)小。左(zuo)心(xin)(xin)(xin)(xin)(xin)一般(ban)不(bu)大(da),偶(ou)見左(zuo)心(xin)(xin)(xin)(xin)(xin)室(shi)增(zeng)(zeng)大(da)。
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心電圖查:右心(xin)室肥(fei)大及(或)右心(xin)房肥(fei)大是肺心(xin)病心(xin)電圖的(de)特征性(xing)改變(bian)(bian)。并有一(yi)定易變(bian)(bian)性(xing),急性(xing)發作期由于缺氧(yang)、酸中(zhong)毒、堿中(zhong)毒、電解質紊亂等可引(yin)起(qi)ST段與T波改變(bian)(bian)和各種心(xin)律(lv)失常(chang),當解除誘因,病情緩解后常(chang)可有所(suo)恢復及心(xin)律(lv)失常(chang)等消失,常(chang)見改變(bian)(bian)為(wei):
1、P波變化額向P波電軸右偏在+70°~+90°之間。Ⅱ、Ⅲ、aVF導(dao)聯(lian)中(zhong)P波高(gao)尖(jian),振(zhen)幅可達0.22mV或(huo)以上、稱"肺型(xing)P波"。如P>0.25mV,則(ze)診斷肺心病的敏感(gan)性(xing)、特異性(xing)和準確性(xing)均增高(gao)。
2、QRS波(bo)(bo)群和(he)T波(bo)(bo)變化(hua)額(e)面(mian)QRS波(bo)(bo)群平(ping)均(jun)電(dian)(dian)(dian)軸(zhou)右偏(pian)≥+90°。有(you)(you)時電(dian)(dian)(dian)軸(zhou)極(ji)度右偏(pian)呈SⅠ、SⅡ、SⅢ的電(dian)(dian)(dian)軸(zhou)左(zuo)偏(pian)假象。右側胸導聯出(chu)現(xian)(xian)高R波(bo)(bo)。V5呈深S波(bo)(bo),顯著右心(xin)(xin)室(shi)肥大。有(you)(you)時在V3R、V1導聯可(ke)出(chu)現(xian)(xian)q波(bo)(bo),或在V1~V5導聯都呈QS與rS波(bo)(bo)形。重度肺(fei)氣患者(zhe)如心(xin)(xin)電(dian)(dian)(dian)圖(tu)從正常轉至出(chu)現(xian)(xian)不全(quan)性右束支傳導阻滯(zhi),往(wang)往(wang)表(biao)(biao)示有(you)(you)右心(xin)(xin)負(fu)荷(he)過重,具有(you)(you)一(yi)定診斷價(jia)值。極(ji)少(shao)數患者(zhe)有(you)(you)左(zuo)心(xin)(xin)室(shi)肥大的心(xin)(xin)電(dian)(dian)(dian)圖(tu)改(gai)變,這(zhe)(zhe)可(ke)能由于(yu)合并高血壓、冠心(xin)(xin)病(bing)或支氣管(guan)動脈(mo)分(fen)支擴張有(you)(you)左(zuo)到右分(fen)流(liu),左(zuo)室(shi)泵出(chu)比右室(shi)更多血流(liu)而肥厚所致。Ⅱ、Ⅲ、aVF導聯和(he)右側胸導聯的T波(bo)(bo)可(ke)倒(dao)置(zhi)。可(ke)出(chu)現(xian)(xian)各(ge)種(zhong)心(xin)(xin)律失(shi)常。此外,肺(fei)心(xin)(xin)病(bing)常出(chu)現(xian)(xian)肢(zhi)體導聯低電(dian)(dian)(dian)壓、順鐘向轉位等心(xin)(xin)電(dian)(dian)(dian)圖(tu)改(gai)變,這(zhe)(zhe)類表(biao)(biao)現(xian)(xian)也(ye)見于(yu)肺(fei)氣腫,因此不能作為診斷肺(fei)心(xin)(xin)病(bing)的心(xin)(xin)電(dian)(dian)(dian)圖(tu)改(gai)變
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心向量圖檢查:主要表現為(wei)右心室肥(fei)大(da)(da)和(he)(或右心房(fang)增(zeng)(zeng)大(da)(da),隨(sui)右心室肥(fei)大(da)(da)的程度(du)加(jia)重,QRS方位由正常的左下(xia)(xia)前(qian)或后逐漸演(yan)變(bian)為(wei)向后,再向下(xia)(xia),最后轉向右前(qian),但終末部仍在(zai)右后。QRS環自逆鐘向運動或8字型發展至重度(du)時之順(shun)鐘向運行。P環多狹窄(zhai),左側面與前(qian)額面P環振幅增(zeng)(zeng)大(da)(da),最大(da)(da)向量(liang)向前(qian)下(xia)(xia)、左或右。一般來說,右心房(fang)肥(fei)大(da)(da)越明顯,則P環向量(liang)越向右。
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超聲心動圖檢查:可(ke)顯(xian)著肺總動(dong)脈舒(shu)張期(qi)內(nei)(nei)徑(jing)明顯(xian)增(zeng)大,右(you)(you)肺動(dong)脈內(nei)(nei)徑(jing)增(zeng)大,右(you)(you)心室流出道增(zeng)寬伴舒(shu)張末期(qi)內(nei)(nei)徑(jing)增(zeng)大,右(you)(you)心室內(nei)(nei)徑(jing)增(zeng)大和右(you)(you)心室前壁及室間(jian)隔(ge)厚度(du)增(zeng)加,搏動(dong)幅(fu)度(du)增(zeng)強。多普勒(le)超聲(sheng)心動(dong)圖(tu)時(shi)現三尖瓣返流及右(you)(you)室收縮壓增(zeng)高。多普勒(le)頻譜(pu)分析(xi)可(ke)顯(xian)示(shi)右(you)(you)室射血時(shi)間(jian)縮短,右(you)(you)室射血前期(qi)延(yan)長。
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肺功能檢查:在心(xin)肺(fei)功能(neng)衰竭(jie)期(qi)不宜進(jin)行本檢(jian)查(cha),癥狀緩解期(qi)中可(ke)(ke)考(kao)慮測(ce)定。病人均有通氣(qi)(qi)(qi)和(he)換氣(qi)(qi)(qi)功能(neng)障礙。表現為(wei)時間(jian)肺(fei)活量及最大(da)通氣(qi)(qi)(qi)量減低,殘(can)氣(qi)(qi)(qi)量增加(jia)。用四探頭功能(neng)儀以及γ照相和(he)靜脈彈丸式注射法注入核素133氙測(ce)定兩肺(fei)上下(xia)野半(ban)清除時間(jian)可(ke)(ke)反映(ying)局部通氣(qi)(qi)(qi)功能(neng),比(bi)一般肺(fei)功能(neng)的肺(fei)心(xin)病檢(jian)出率高。(八)右心(xin)導管檢(jian)查(cha)經(jing)靜脈送入漂浮(fu)導管至肺(fei)動脈,直(zhi)接測(ce)定肺(fei)動脈和(he)右心(xin)室壓力,可(ke)(ke)作為(wei)肺(fei)心(xin)病的早(zao)期(qi)診(zhen)斷。
此外,肺(fei)阻抗血(xue)流(liu)(liu)圖(tu)及其微分圖(tu)的檢查(cha)在(zai)一定程度上能(neng)(neng)反映機(ji)體內肺(fei)血(xue)流(liu)(liu)容積改變,了解肺(fei)循(xun)環血(xue)流(liu)(liu)動(dong)力學變化,肺(fei)動(dong)脈(mo)壓(ya)力大小和右心功(gong)能(neng)(neng);核(he)素心血(xue)管造影有(you)助(zhu)于(yu)了解右心室(shi)功(gong)能(neng)(neng)改變;肺(fei)灌注掃描(miao)如肺(fei)上部(bu)血(xue)流(liu)(liu)增加,下部(bu)減少,則提示有(you)肺(fei)動(dong)脈(mo)高壓(ya)存在(zai)。
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