早期癥狀
乳(ru)腺腫(zhong)(zhong)瘤腫(zhong)(zhong)塊(kuai)位于外(wai)上象(xiang)限最多見,其次是乳(ru)頭(tou)(tou)、乳(ru)暈區和內上象(xiang)限。因多無自覺(jue)癥(zheng)狀,腫(zhong)(zhong)塊(kuai)常是病人在無意(yi)中(如洗澡、更衣(yi))發現的。少(shao)數病人可(ke)有不同(tong)程度的觸痛或刺激(ji)和乳(ru)頭(tou)(tou)溢液。腫(zhong)(zhong)塊(kuai)的生(sheng)長(chang)速度較快,侵及周圍組織(zhi)可(ke)引(yin)起乳(ru)房(fang)外(wai)形(xing)的改(gai)(gai)變,出(chu)現一系列體征。如:腫(zhong)(zhong)瘤表面(mian)皮(pi)膚凹(ao)陷;鄰近乳(ru)頭(tou)(tou)的癌腫(zhong)(zhong)可(ke)將乳(ru)頭(tou)(tou)牽(qian)向癌腫(zhong)(zhong)方向;乳(ru)頭(tou)(tou)內陷等。癌腫(zhong)(zhong)較大者,可(ke)使整個乳(ru)房(fang)組織(zhi)收縮,腫(zhong)(zhong)塊(kuai)明顯凸出(chu)。癌腫(zhong)(zhong)繼(ji)續增長(chang),形(xing)成所謂“桔皮(pi)樣”改(gai)(gai)變。這些都是乳(ru)腺腫(zhong)(zhong)瘤的重要癥(zheng)狀。
乳腺腫塊
乳腺腫(zhong)塊是乳腺腫(zhong)瘤最(zui)常見的癥(zheng)狀,約90%的患者是以該癥(zheng)狀前來就診的。隨著腫(zhong)瘤知識(shi)的普及(ji),防(fang)癌普查(cha)的開展,這一比例或許還會(hui)增加(jia)。若乳腺出現腫(zhong)塊,應(ying)對以下幾個方面(mian)加(jia)以了解。
1、部位:乳腺以乳頭為中(zhong)心,做一十(shi)字(zi)交叉,可(ke)將乳腺分為內上,外(wai)上,內下,外(wai)下及(ji)中(zhong)央(乳暈部)5個區。而乳腺腫瘤以外(wai)上多見,其次是內上。內下、外(wai)下較(jiao)少見。
2、數目(mu):乳(ru)腺(xian)腫(zhong)瘤(liu)(liu)以(yi)單側(ce)乳(ru)腺(xian)的單發腫(zhong)塊(kuai)(kuai)為多見,單側(ce)多發腫(zhong)塊(kuai)(kuai)及原發雙側(ce)乳(ru)腺(xian)腫(zhong)瘤(liu)(liu)臨床(chuang)上并不多見。但隨(sui)著腫(zhong)瘤(liu)(liu)防治水平的提高,患者生存期不斷延長,一側(ce)乳(ru)腺(xian)腫(zhong)瘤(liu)(liu)術(shu)后,對側(ce)乳(ru)腺(xian)發生第二個原發癌腫(zhong)的機會將增(zeng)多。
3、大小(xiao):早(zao)期乳(ru)(ru)(ru)腺(xian)腫(zhong)(zhong)(zhong)瘤的(de)腫(zhong)(zhong)(zhong)塊(kuai)一般較小(xiao),有(you)時(shi)與小(xiao)葉(xie)增生或一些(xie)良性病變不易區分(fen)。但即使很小(xiao)的(de)腫(zhong)(zhong)(zhong)塊(kuai)有(you)時(shi)也會累及乳(ru)(ru)(ru)腺(xian)懸韌帶,而引起局部皮膚的(de)凹(ao)陷或乳(ru)(ru)(ru)頭回縮等癥(zheng)狀,較易早(zao)期發現。以(yi)往(wang)(wang)因醫(yi)療保健水平較差,來就(jiu)診時(shi),腫(zhong)(zhong)(zhong)塊(kuai)往(wang)(wang)往(wang)(wang)較大。現今,隨著(zhu)乳(ru)(ru)(ru)腺(xian)自我檢查的(de)普(pu)(pu)及和普(pu)(pu)查工作的(de)開展,臨床(chuang)上早(zao)期乳(ru)(ru)(ru)腺(xian)腫(zhong)(zhong)(zhong)瘤有(you)所增多。
4、形態和(he)邊界:乳(ru)腺腫(zhong)瘤絕大多數(shu)(shu)呈浸(jin)潤性生(sheng)長,邊界欠清。有(you)的(de)(de)可呈扁平(ping)狀(zhuang),表面不光滑,有(you)結節感。但(dan)需注意的(de)(de)是,腫(zhong)塊越小,上(shang)述癥狀(zhuang)越不明顯(xian),而且少數(shu)(shu)特殊類型的(de)(de)乳(ru)腺腫(zhong)瘤可因浸(jin)潤較輕,呈膨脹性生(sheng)長,表現為光滑、活(huo)動、邊界清楚,與(yu)良性腫(zhong)瘤不易區(qu)別(bie)。
5、硬度(du):乳腺(xian)腫瘤腫塊質地較(jiao)硬,但富于細胞的(de)髓樣癌可稍軟(ruan),個(ge)別也(ye)可呈囊(nang)性(xing),如(ru)囊(nang)性(xing)乳頭狀癌。少數腫塊周圍,有(you)(you)較(jiao)多(duo)脂肪組織包裹觸(chu)診時有(you)(you)柔韌感(gan)。
6、活動(dong)度:腫(zhong)塊較小時,活動(dong)度較大,但這(zhe)種活動(dong)是腫(zhong)塊與(yu)其周(zhou)圍(wei)組織一(yi)(yi)起活動(dong),與(yu)纖維(wei)腺(xian)(xian)瘤(liu)(liu)活動(dong)度不同。若腫(zhong)瘤(liu)(liu)侵犯胸(xiong)大肌筋膜,則活動(dong)度減(jian)弱;腫(zhong)瘤(liu)(liu)進一(yi)(yi)部(bu)累及胸(xiong)大肌,則活動(dong)消失(shi)。讓(rang)患者雙手叉腰挺胸(xiong)使胸(xiong)肌收縮,可見兩側(ce)乳腺(xian)(xian)明顯不對稱。晚期乳腺(xian)(xian)腫(zhong)瘤(liu)(liu)可侵及胸(xiong)壁,則完全固(gu)定,腫(zhong)瘤(liu)(liu)周(zhou)圍(wei)淋巴結受侵,皮膚水(shui)腫(zhong)可以呈橘皮狀,稱“橘皮征”,腫(zhong)瘤(liu)(liu)周(zhou)圍(wei)皮下出現結節稱“衛星結節”。
在乳(ru)(ru)腺(xian)良性腫瘤中(zhong),表(biao)現為(wei)乳(ru)(ru)腺(xian)腫塊的也不少見(jian),其中(zhong)最常見(jian)的是(shi)乳(ru)(ru)腺(xian)纖維腺(xian)瘤。該(gai)病以年輕女性多見(jian),40歲以上發(fa)病率低。腫瘤常為(wei)實(shi)性、質韌、有完(wan)整包(bao)膜(mo)、表(biao)面光滑(hua)、觸摸有滑(hua)動感(gan),一般無(wu)皮膚粘連,亦不引起乳(ru)(ru)頭(tou)(tou)回縮。導管(guan)內乳(ru)(ru)頭(tou)(tou)狀瘤,腫塊常很(hen)小,不易捫及。稍大者可在乳(ru)(ru)暈周圍(wei)捫及小結節(jie),臨床(chuang)以乳(ru)(ru)頭(tou)(tou)溢液為(wei)主(zhu)要癥狀。乳(ru)(ru)腺(xian)小葉增生很(hen)少形成(cheng)清晰的腫塊,而以局部乳(ru)(ru)腺(xian)組織(zhi)增厚(hou)為(wei)主(zhu),質地較韌,無(wu)包(bao)膜(mo)感(gan),在月經來潮前(qian)常有脹痛。
有(you)些僅表(biao)現為乳腺局(ju)部腺體增(zeng)厚(hou)并無明(ming)顯腫塊(kuai),無清楚邊(bian)界,大多數被(bei)診斷為“乳腺增(zeng)生”。但仔細檢查增(zeng)厚(hou)區較局(ju)限,同(tong)時伴有(you)少許(xu)皮(pi)膚(fu)粘連時應引起(qi)注(zhu)意,可以作乳房攝片。
乳腺疼痛
乳(ru)(ru)腺(xian)(xian)疼(teng)痛(tong)雖可(ke)見于(yu)多種乳(ru)(ru)腺(xian)(xian)疾病,但疼(teng)痛(tong)并不是乳(ru)(ru)腺(xian)(xian)腫(zhong)瘤的(de)(de)常見癥狀,不論良(liang)性或(huo)惡性乳(ru)(ru)腺(xian)(xian)腫(zhong)瘤通常總(zong)是無痛(tong)的(de)(de)。在早(zao)期乳(ru)(ru)腺(xian)(xian)腫(zhong)瘤中,偶有(you)(you)以疼(teng)痛(tong)為唯一癥狀的(de)(de),可(ke)為鈍痛(tong)或(huo)牽拉(la)感,側(ce)臥時尤甚(shen)。有(you)(you)研(yan)究顯示,絕經(jing)后女(nv)性出(chu)現乳(ru)(ru)腺(xian)(xian)疼(teng)痛(tong)并伴有(you)(you)腺(xian)(xian)體增厚者,乳(ru)(ru)腺(xian)(xian)腫(zhong)瘤檢出(chu)率將增高。當(dang)然,腫(zhong)瘤伴有(you)(you)炎癥時可(ke)以有(you)(you)脹(zhang)痛(tong)或(huo)壓痛(tong)。晚期腫(zhong)瘤若侵及神經(jing)或(huo)腋(ye)淋巴結腫(zhong)大壓迫或(huo)侵犯(fan)臂叢神經(jing)時可(ke)有(you)(you)肩部脹(zhang)痛(tong)。
乳頭溢液
乳頭溢(yi)液(ye)有生(sheng)(sheng)理(li)性(xing)(xing)(xing)和(he)病(bing)理(li)性(xing)(xing)(xing)之(zhi)分(fen)。生(sheng)(sheng)理(li)性(xing)(xing)(xing)乳頭溢(yi)液(ye)主要見于(yu)妊娠和(he)哺乳期女(nv)性(xing)(xing)(xing)。病(bing)理(li)性(xing)(xing)(xing)乳頭溢(yi)液(ye)是(shi)(shi)指非生(sheng)(sheng)理(li)狀態下(xia)的(de)(de)乳腺(xian)導(dao)管泌液(ye)。通常所說(shuo)的(de)(de)即指后者。乳頭溢(yi)液(ye)可因(yin)多種乳腺(xian)疾病(bing)而引起,也較易為(wei)患者注意,是(shi)(shi)臨床上(shang)約10%的(de)(de)患者前來就診的(de)(de)主要原因(yin)之(zhi)一,在各種乳腺(xian)疾病(bing)的(de)(de)癥狀中(zhong),其發(fa)生(sheng)(sheng)率僅次于(yu)乳腺(xian)腫塊和(he)乳腺(xian)疼痛(tong)。
1、乳(ru)頭(tou)溢(yi)液(ye)(ye)(ye)按其物理性(xing)(xing)狀可(ke)(ke)分為:血(xue)性(xing)(xing)、血(xue)清(qing)樣(yang)(yang)(yang)(yang)、漿液(ye)(ye)(ye)性(xing)(xing)、水樣(yang)(yang)(yang)(yang)、膿(nong)性(xing)(xing)、乳(ru)汁(zhi)樣(yang)(yang)(yang)(yang)等。其中漿液(ye)(ye)(ye)性(xing)(xing)、水樣(yang)(yang)(yang)(yang)和乳(ru)汁(zhi)樣(yang)(yang)(yang)(yang)溢(yi)液(ye)(ye)(ye)較(jiao)為常見,血(xue)性(xing)(xing)溢(yi)液(ye)(ye)(ye)只占溢(yi)液(ye)(ye)(ye)病例的10%。病變位于(yu)大(da)導(dao)管(guan)時(shi),溢(yi)液(ye)(ye)(ye)多呈(cheng)血(xue)性(xing)(xing);位于(yu)較(jiao)小導(dao)管(guan)時(shi),可(ke)(ke)為淡血(xue)性(xing)(xing)或漿液(ye)(ye)(ye)性(xing)(xing);如血(xue)液(ye)(ye)(ye)在導(dao)管(guan)內(nei)停留過久,可(ke)(ke)呈(cheng)暗褐色;導(dao)管(guan)內(nei)有(you)炎癥(zheng)合并(bing)感(gan)染時(shi),可(ke)(ke)混有(you)膿(nong)汁(zhi),液(ye)(ye)(ye)化(hua)壞死組織可(ke)(ke)呈(cheng)水樣(yang)(yang)(yang)(yang)、乳(ru)汁(zhi)樣(yang)(yang)(yang)(yang)或棕(zong)色液(ye)(ye)(ye);乳(ru)腺導(dao)管(guan)擴張癥(zheng)液(ye)(ye)(ye)體常為漿液(ye)(ye)(ye)性(xing)(xing)。血(xue)性(xing)(xing)溢(yi)液(ye)(ye)(ye)大(da)多由良性(xing)(xing)病變引(yin)起,有(you)少數乳(ru)腺腫(zhong)瘤(liu)亦可(ke)(ke)呈(cheng)血(xue)性(xing)(xing)。生理性(xing)(xing)乳(ru)頭(tou)溢(yi)液(ye)(ye)(ye)多為雙(shuang)側性(xing)(xing),其溢(yi)液(ye)(ye)(ye)常呈(cheng)乳(ru)汁(zhi)樣(yang)(yang)(yang)(yang)或水樣(yang)(yang)(yang)(yang)。
2、乳頭溢液(ye)的病因主要分為(wei):乳外因素(su)和(he)乳內因素(su)。
乳(ru)腺(xian)腫(zhong)瘤患(huan)者(zhe)有5%~10%有乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye),但以乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye)為唯一(yi)癥狀(zhuang)僅1%。溢(yi)(yi)液(ye)(ye)(ye)常為單(dan)管(guan)(guan)性(xing),性(xing)狀(zhuang)可以多(duo)種多(duo)樣(yang),如血性(xing),漿液(ye)(ye)(ye)性(xing),水樣(yang)或無色。乳(ru)腺(xian)腫(zhong)瘤原(yuan)發(fa)于大導(dao)(dao)管(guan)(guan)者(zhe)或形態(tai)屬(shu)導(dao)(dao)管(guan)(guan)內(nei)(nei)癌者(zhe)合并乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye)較多(duo)見(jian),如導(dao)(dao)管(guan)(guan)內(nei)(nei)乳(ru)頭(tou)狀(zhuang)瘤惡變,乳(ru)頭(tou)濕疹樣(yang)癌等均可以有乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye)。值得注意的是,盡(jin)管(guan)(guan)多(duo)數人認為乳(ru)腺(xian)腫(zhong)瘤甚少伴發(fa)乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye),而且即(ji)使出現(xian)(xian)溢(yi)(yi)液(ye)(ye)(ye)都幾乎在(zai)出現(xian)(xian)腫(zhong)塊之(zhi)后或同時出現(xian)(xian),不伴腫(zhong)塊者(zhe)甚少考慮為癌。但近來研究(jiu)表(biao)(biao)明,乳(ru)頭(tou)溢(yi)(yi)液(ye)(ye)(ye)是某(mou)些(xie)乳(ru)腺(xian)腫(zhong)瘤,特別(bie)是導(dao)(dao)管(guan)(guan)內(nei)(nei)癌較早期的臨(lin)床表(biao)(biao)現(xian)(xian),而且在(zai)未形成明顯腫(zhong)塊之(zhi)前即(ji)可單(dan)獨存(cun)在(zai)。
導管(guan)內乳(ru)頭(tou)狀瘤(liu)是較(jiao)多(duo)(duo)發(fa)生乳(ru)頭(tou)溢(yi)液的疾病,占全部乳(ru)頭(tou)溢(yi)液病變的首(shou)位,其中(zhong)又(you)以乳(ru)暈區導管(guan)內乳(ru)頭(tou)狀瘤(liu)多(duo)(duo)見,可單發(fa)或(huo)多(duo)(duo)發(fa),年齡分(fen)布在18~80歲不等,主要(yao)30~50歲多(duo)(duo)見。腫瘤(liu)直(zhi)徑0.3~3.0cm不等,平均1.0cm,大于3.0cm常為(wei)(wei)(wei)惡(e)性可能。溢(yi)液性質多(duo)(duo)為(wei)(wei)(wei)血性或(huo)漿液性,其他少見。一般認為(wei)(wei)(wei)發(fa)生于大導管(guan)的乳(ru)頭(tou)狀瘤(liu)多(duo)(duo)為(wei)(wei)(wei)單發(fa),甚(shen)少癌變,而(er)中(zhong)小導管(guan)者則常為(wei)(wei)(wei)多(duo)(duo)發(fa),可見癌變。兩者為(wei)(wei)(wei)同類(lei)病變,只(zhi)是發(fa)生部位、生長過(guo)程不同而(er)已。
囊(nang)性(xing)增生病雖非腫瘤,但是(shi)乳腺組織最(zui)常(chang)見的良性(xing)病變,多見于40歲左右,絕(jue)經(jing)后少見。其(qi)中,囊(nang)腫、乳管上皮(pi)增生、乳頭狀瘤病三種病理改(gai)變是(shi)其(qi)溢(yi)液的基礎。性(xing)質多為漿(jiang)液性(xing),本病合并溢(yi)液只占(zhan)5%。
乳頭改變
乳(ru)(ru)腺腫(zhong)瘤患(huan)者若有(you)乳(ru)(ru)頭(tou)異常改變,通(tong)常表現為乳(ru)(ru)頭(tou)糜爛或(huo)乳(ru)(ru)頭(tou)回縮。
1、乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)糜爛:有一種乳(ru)(ru)(ru)(ru)(ru)腺(xian)(xian)Paget病的(de)(de)典(dian)型表現,常伴瘙癢,約2/3患者(zhe)可伴有乳(ru)(ru)(ru)(ru)(ru)暈或(huo)乳(ru)(ru)(ru)(ru)(ru)房其他部(bu)位(wei)的(de)(de)腫塊(kuai)。起始,只(zhi)有乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)脫屑(xie)(xie)或(huo)乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)小裂(lie)隙。乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)脫屑(xie)(xie)常伴有少量分泌物并結(jie)痂(jia),揭去痂(jia)皮可見鮮紅(hong)糜爛面(mian),經(jing)久不(bu)愈。當(dang)整(zheng)(zheng)個乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)受累后(hou),可進(jin)一部(bu)侵及(ji)周圍組織,隨著(zhu)病變的(de)(de)進(jin)展,乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)可因之而整(zheng)(zheng)個消失。部(bu)分患者(zhe)也可先出(chu)現乳(ru)(ru)(ru)(ru)(ru)腺(xian)(xian)腫塊(kuai),爾后(hou)出(chu)現乳(ru)(ru)(ru)(ru)(ru)頭(tou)(tou)病變。
2、乳(ru)(ru)頭(tou)回縮(suo)(suo):當腫(zhong)(zhong)(zhong)(zhong)瘤侵(qin)及乳(ru)(ru)頭(tou)或乳(ru)(ru)暈下區時(shi)(shi)(shi)(shi),乳(ru)(ru)腺(xian)的纖維(wei)組織(zhi)和導(dao)管系(xi)統可(ke)因此而縮(suo)(suo)短(duan),牽(qian)拉乳(ru)(ru)頭(tou),使其(qi)凹陷(xian)(xian),偏向,甚至(zhi)完全縮(suo)(suo)入乳(ru)(ru)暈后方。此時(shi)(shi)(shi)(shi),患側乳(ru)(ru)頭(tou)常較健側高(gao)。可(ke)能出現(xian)在早(zao)期乳(ru)(ru)腺(xian)腫(zhong)(zhong)(zhong)(zhong)瘤,但有時(shi)(shi)(shi)(shi)也是晚期體征,主要取決(jue)于腫(zhong)(zhong)(zhong)(zhong)瘤的生長部(bu)位。當腫(zhong)(zhong)(zhong)(zhong)瘤在乳(ru)(ru)頭(tou)下或附(fu)近時(shi)(shi)(shi)(shi),早(zao)期即可(ke)出現(xian);若腫(zhong)(zhong)(zhong)(zhong)瘤位于乳(ru)(ru)腺(xian)深部(bu)組織(zhi)中,距乳(ru)(ru)頭(tou)較遠時(shi)(shi)(shi)(shi),出現(xian)這(zhe)一(yi)體征通常已(yi)是晚期。當然,乳(ru)(ru)頭(tou)回縮(suo)(suo),凹陷(xian)(xian)并非均是惡性病變,部(bu)分可(ke)因先天發(fa)育不良(liang)造成(cheng)或慢性炎癥引起,此時(shi)(shi)(shi)(shi),乳(ru)(ru)頭(tou)可(ke)用手指牽(qian)出,非固定。
皮膚改變
乳腺腫(zhong)瘤引起(qi)皮膚的(de)改變,與腫(zhong)瘤的(de)部位、深淺(qian)和(he)侵(qin)犯程度有(you)關,通常有(you)以下(xia)幾(ji)種(zhong)表現:
1、皮(pi)(pi)膚粘連:乳(ru)腺位于深淺(qian)兩筋膜(mo)(mo)之(zhi)間,淺(qian)筋膜(mo)(mo)的淺(qian)層與皮(pi)(pi)膚相(xiang)連,深層附于胸大(da)(da)肌淺(qian)面(mian)。淺(qian)筋膜(mo)(mo)在(zai)乳(ru)腺組織(zhi)內形(xing)成(cheng)小葉間隔,即乳(ru)房(fang)懸韌(ren)帶(dai)。當腫瘤(liu)(liu)侵及(ji)這些韌(ren)帶(dai)時,可使之(zhi)收縮,變短,牽拉皮(pi)(pi)膚形(xing)成(cheng)凹(ao)陷(xian)(xian),狀如(ru)酒(jiu)窩(wo),故稱“酒(jiu)窩(wo)征”。當腫瘤(liu)(liu)較小時,可引(yin)起極輕(qing)微(wei)(wei)的皮(pi)(pi)膚粘連,不(bu)易察(cha)覺(jue)。此(ci)時,需在(zai)較好的采光(guang)條件下,輕(qing)托患乳(ru),使其表面(mian)張力增大(da)(da),在(zai)移(yi)動乳(ru)房(fang)時多可見(jian)腫瘤(liu)(liu)表面(mian)皮(pi)(pi)膚有輕(qing)微(wei)(wei)牽拉、凹(ao)陷(xian)(xian)等現象。如(ru)有此(ci)癥狀者應警惕乳(ru)腺腫瘤(liu)(liu)可能,良性(xing)腫瘤(liu)(liu)很少(shao)有此(ci)癥狀。
2、皮膚淺(qian)表(biao)靜脈(mo)(mo)曲張(zhang)(zhang):腫(zhong)瘤(liu)體積較大(da)或生長較快時,可使其表(biao)面(mian)皮膚變得菲薄(bo),其下淺(qian)表(biao)血管,靜脈(mo)(mo)常(chang)可曲張(zhang)(zhang)。在(zai)液晶(jing)熱圖和(he)紅外線(xian)掃描時更(geng)為清晰,常(chang)見于乳腺巨纖維腺瘤(liu)和(he)分葉狀囊肉瘤(liu)。在(zai)急性炎癥(zheng)期(qi)、妊娠(shen)期(qi)、哺乳期(qi)的腫(zhong)瘤(liu)也常(chang)有淺(qian)表(biao)靜脈(mo)(mo)曲張(zhang)(zhang)。
3、皮膚發紅(hong):急、慢(man)性(xing)乳(ru)腺(xian)炎(yan)時(shi)(shi),乳(ru)腺(xian)皮膚可有(you)紅(hong)腫(zhong)。但在(zai)乳(ru)腺(xian)腫(zhong)瘤中,主要見于(yu)炎(yan)性(xing)乳(ru)腺(xian)腫(zhong)瘤。由于(yu)其皮下淋(lin)巴(ba)(ba)管全為癌(ai)(ai)栓(shuan)所(suo)占可引起癌(ai)(ai)性(xing)淋(lin)巴(ba)(ba)管炎(yan),此(ci)時(shi)(shi)皮膚顏色(se)淡紅(hong)到深紅(hong),開始比(bi)較局限,不久擴展(zhan)至大部分乳(ru)房皮膚,同時(shi)(shi)伴皮膚水腫(zhong)、增厚、皮膚溫度(du)升高(gao)等。
4、皮膚水腫(zhong):由于乳(ru)腺皮下淋(lin)(lin)巴(ba)(ba)(ba)管(guan)被(bei)腫(zhong)瘤細胞阻塞(sai)或(huo)乳(ru)腺中央區被(bei)腫(zhong)瘤細胞浸潤,使乳(ru)腺淋(lin)(lin)巴(ba)(ba)(ba)管(guan)回流受阻,淋(lin)(lin)巴(ba)(ba)(ba)管(guan)內淋(lin)(lin)巴(ba)(ba)(ba)液積聚,皮膚變厚,毛囊(nang)口(kou)擴(kuo)大、深(shen)陷而顯示“橘(ju)皮樣改變”。在肥胖,下垂的乳(ru)房常見其外下方有輕度(du)皮膚水腫(zhong),如雙側(ce)對稱,乃因局部循(xun)環(huan)障礙所致;如為單側(ce),則要慎重,提防癌瘤可能。
此外(wai),晚期乳腺腫瘤(liu)尚可(ke)直接侵犯皮膚(fu)引起潰瘍(yang),若(ruo)合并細菌感染,氣(qi)味難(nan)聞。癌細胞若(ruo)浸潤到皮內并生長,可(ke)在主病灶的(de)周圍皮膚(fu)形(xing)成(cheng)散在的(de)硬(ying)質結節,即“皮膚(fu)衛星(xing)結節”。
腋窩淋巴結腫大
乳腺(xian)腫(zhong)瘤逐步(bu)(bu)發展,可(ke)侵(qin)及(ji)淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)管,向其(qi)局部淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)引(yin)(yin)流(liu)區轉移。其(qi)中,最常見的淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)轉移部位是(shi)同側(ce)腋(ye)(ye)窩淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)。淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)常由小逐步(bu)(bu)增大(da)(da),淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)數(shu)目由少逐步(bu)(bu)增多,起(qi)初,腫(zhong)大(da)(da)的淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)可(ke)以(yi)推動(dong),最后相互融合,固定。腫(zhong)大(da)(da)的淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)如果(guo)侵(qin)犯(fan)、壓(ya)迫腋(ye)(ye)靜脈常可(ke)使同側(ce)上肢(zhi)水腫(zhong);如侵(qin)及(ji)臂(bei)叢神經時引(yin)(yin)起(qi)肩部酸痛。檢查腋(ye)(ye)窩淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)時,應使患(huan)側(ce)上肢(zhi)盡量(liang)放松,這樣(yang)才可(ke)捫及(ji)腋(ye)(ye)頂。若能觸(chu)及(ji)腫(zhong)大(da)(da)淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)尚需(xu)注意(yi)淋(lin)(lin)(lin)巴(ba)(ba)(ba)(ba)(ba)結(jie)(jie)的數(shu)目、大(da)(da)小、質地、活動(dong)度及(ji)其(qi)表面情況(kuang),以(yi)和炎癥(zheng)、結(jie)(jie)核相鑒別。
如果乳(ru)(ru)房內未及腫(zhong)塊(kuai),而以腋窩(wo)(wo)淋(lin)(lin)巴結腫(zhong)大為(wei)第(di)一(yi)癥(zheng)狀而來就(jiu)診(zhen)的(de)比較(jiao)少,當腋窩(wo)(wo)淋(lin)(lin)巴結腫(zhong)大,病理證實是轉(zhuan)移癌時,除仔細檢查其淋(lin)(lin)巴引流區(qu)外,尚要排除肺和(he)消化道的(de)腫(zhong)瘤(liu)。若病理提示是轉(zhuan)移性腺(xian)癌,要注(zhu)意“隱(yin)匿性乳(ru)(ru)腺(xian)腫(zhong)瘤(liu)”可能(neng)。此時,多未能(neng)發現(xian)乳(ru)(ru)房病灶,鉬靶攝片(pian)或許有助于診(zhen)斷。淋(lin)(lin)巴結行激素受體測定,若陽性,即使各項(xiang)檢查都未能(neng)發現(xian)乳(ru)(ru)房內病灶,仍(reng)然要考慮(lv)乳(ru)(ru)腺(xian)來源的(de)腫(zhong)瘤(liu)。
乳腺腫瘤可(ke)向同側腋窩淋巴(ba)結(jie)轉(zhuan)移(yi),還可(ke)通(tong)過前胸壁和內乳淋巴(ba)網的相互交通(tong),向對側腋窩淋巴(ba)結(jie)轉(zhuan)移(yi),發(fa)生(sheng)率約5%左(zuo)右。此外,晚期乳腺腫瘤尚可(ke)有(you)同側鎖骨(gu)(gu)上(shang)(shang)淋巴(ba)結(jie)轉(zhuan)移(yi),甚至(zhi)對側鎖骨(gu)(gu)上(shang)(shang)淋巴(ba)結(jie)轉(zhuan)移(yi)。