膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)結(jie)石(shi)是指肝(gan)內(nei)外膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)內(nei)有結(jie)石(shi)形成(cheng),是最常見的膽(dan)(dan)(dan)(dan)道系(xi)統(tong)疾病(bing)。結(jie)石(shi)阻(zu)塞膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)引起膽(dan)(dan)(dan)(dan)汁淤滯,繼(ji)發(fa)細菌感(gan)染(ran)而(er)(er)導(dao)致急性(xing)膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)炎(yan)發(fa)生。膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)反復炎(yan)癥可造成(cheng)局部管(guan)(guan)(guan)(guan)壁增厚或疤痕性(xing)狹窄(zhai),而(er)(er)膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)炎(yan)癥和狹窄(zhai)又可以(yi)促進結(jie)石(shi)形成(cheng)。膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)狹窄(zhai)近端被動擴(kuo)張,內(nei)壓增高。臨(lin)床上病(bing)人(ren)常出現(xian)右上腹絞痛,發(fa)冷發(fa)熱(re),黃(huang)疸夏科氏(charcot)三聯征(zheng)。感(gan)染(ran)嚴重可出現(xian)休克和精神異常(Reynokds五聯征(zheng)),癥狀反復久(jiu)之出現(xian)膽(dan)(dan)(dan)(dan)汁性(xing)肝(gan)硬(ying)化,繼(ji)而(er)(er)出現(xian)門靜(jing)脈(mo)高壓癥。膽(dan)(dan)(dan)(dan)石(shi)癥是我國常見病(bing),國人(ren)發(fa)病(bing)率(lv)(lv)約在10%左右,膽(dan)(dan)(dan)(dan)管(guan)(guan)(guan)(guan)結(jie)石(shi)以(yi)華南地區(qu)發(fa)病(bing)率(lv)(lv)高,尤其農村地區(qu),該病(bing)的發(fa)生與膽(dan)(dan)(dan)(dan)道蛔蟲、膽(dan)(dan)(dan)(dan)道感(gan)染(ran)及膽(dan)(dan)(dan)(dan)道梗阻(zu)有關。
膽管結石(shi)以發病率高(gao)、排(pai)石(shi)不(bu)通、溶石(shi)困(kun)難(nan)等為特(te)點,國內(nei)外均沒有特(te)效療法,從而(er)使(shi)眾(zhong)多的(de)肝(gan)內(nei)膽管結石(shi)患者(zhe)因缺乏有效治療而(er)引起膽汁淤(yu)積、肝(gan)硬化(hua)甚至肝(gan)癌。