膽(dan)道蛔(hui)蟲(chong)病與(yu)肝蛔(hui)蟲(chong)病的(de)的(de)治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)包括非手(shou)(shou)術治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)和手(shou)(shou)術治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)兩(liang)大類。早年對(dui)其治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)以手(shou)(shou)術為主,因當(dang)(dang)時(shi)對(dui)其病理認識不足恐延誤手(shou)(shou)術時(shi)機(ji),加上當(dang)(dang)時(shi)膽(dan)道蛔(hui)蟲(chong)病發生時(shi)往(wang)往(wang)蛔(hui)蟲(chong)數目(mu)較(jiao)多(duo)。目(mu)前治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)原則為解(jie)痙止痛、利膽(dan)驅蟲(chong)、防治(zhi)(zhi)(zhi)(zhi)感染,非手(shou)(shou)術療(liao)(liao)(liao)法多(duo)可治(zhi)(zhi)(zhi)(zhi)愈,但對(dui)非手(shou)(shou)術治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)無效或有嚴重并(bing)發癥的(de)病人可考慮相(xiang)應的(de)手(shou)(shou)術治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)。
一、非手術治療
1、解痙止痛
解(jie)除(chu)痙攣(luan)可(ke)應用(yong)(yong)(yong)抗膽堿能(neng)藥(yao)物(wu)(wu)如(ru)阿托品肌(ji)內(nei)或(huo)皮下注(zhu)射(she),成人每(mei)(mei)次(ci)(ci)0.5~1mg,兒童每(mei)(mei)次(ci)(ci)0.01~0.03mg/kg,也可(ke)用(yong)(yong)(yong)山(shan)莨(lang)菪堿(654-2)肌(ji)注(zhu)或(huo)靜(jing)脈滴注(zhu)。單(dan)用(yong)(yong)(yong)解(jie)痙藥(yao)物(wu)(wu)止痛(tong)效(xiao)果欠佳時(shi)可(ke)加(jia)用(yong)(yong)(yong)鎮(zhen)痛(tong)藥(yao)物(wu)(wu),如(ru)鹽酸哌替啶(ding)50~75mg肌(ji)注(zhu),必要時(shi)4~6h重復應用(yong)(yong)(yong)。因為注(zhu)射(she)鎮(zhen)痛(tong)藥(yao)物(wu)(wu)可(ke)能(neng)引(yin)起Oddi括約肌(ji)痙攣(luan),加(jia)劇疼(teng)痛(tong),所以鎮(zhen)痛(tong)藥(yao)物(wu)(wu)必須(xu)聯合解(jie)痙藥(yao)物(wu)(wu)應用(yong)(yong)(yong)方可(ke)取得(de)較好療效(xiao)。另外加(jia)用(yong)(yong)(yong)維生素K類、黃體酮(tong)等肌(ji)注(zhu)或(huo)穴位注(zhu)射(she)亦有作用(yong)(yong)(yong)。針刺(ci)穴位常取足三(san)里、陽陵泉(quan),還可(ke)選加(jia)太沖、內(nei)關、膽囊(nang)穴等,用(yong)(yong)(yong)強刺(ci)激或(huo)瀉(xie)法,在急(ji)性絞痛(tong)時(shi)常可(ke)取得(de)較好止痛(tong)效(xiao)果。
2、利膽驅蟲
(1)33%硫酸鎂溶液,10ml,3次(ci)/d,口服。
(2)烏梅丸9g,2次/d。
(3)道驅蛔湯(tang):烏梅(mei)12g,川椒9g,使(shi)君子肉15g,苦楝皮(pi)9g,木香9g,枳(zhi)殼9g,延胡索12g,大(da)黃(huang)9g(后下),每天1劑(ji),分2次服。
(4)司匹林0.5g,食醋100~150m1,3次/d,加溫水服。以(yi)上藥物均(jun)有利膽(dan)消炎和(he)排(pai)蟲(chong)作用。驅(qu)除腸道(dao)蛔(hui)蟲(chong)應在癥(zheng)狀(zhuang)緩解期(qi)進(jin)行,應選(xuan)用使(shi)蟲(chong)體麻痹之藥物如哌(pai)嗪(qin)(枸櫞酸哌(pai)嗪(qin))(驅(qu)蛔(hui)靈)、己二酸哌(pai)嗪(qin)、四咪(mi)唑(驅(qu)蟲(chong)凈)、噻嘧啶(驅(qu)蟲(chong)靈,噻吩嘧啶)、噻嘧啶(抗蟲(chong)靈)、阿苯(ben)達(da)唑(腸蟲(chong)清)等(deng)。不宜應用使(shi)蟲(chong)體痙攣收縮的驅(qu)蛔(hui)藥如山道(dao)年(驅(qu)蛔(hui)素)、驅(qu)蟲(chong)丹(dan)(一(yi)粒丹(dan))等(deng)。利膽(dan)驅(qu)蟲(chong)的原則(ze)是增加膽(dan)汁分(fen)泌量,使(shi)膽(dan)汁偏酸,麻痹和(he)抑制蟲(chong)體,使(shi)Oddi括約肌(ji)松弛。癥(zheng)狀(zhuang)消退后,仍須堅持(chi)利膽(dan)排(pai)蟲(chong)1~2周,直至糞便(bian)蟲(chong)卵(luan)轉陰。
3、防治感染
用(yong)上(shang)述利膽中(zhong)西(xi)藥(yao)有一定的(de)(de)抗(kang)(kang)炎作用(yong),初期可暫(zan)時不(bu)用(yong)抗(kang)(kang)菌(jun)(jun)藥(yao)物(wu),但有時待(dai)感(gan)染表現明(ming)顯時再用(yong)會貽誤病情。為防止嚴(yan)重(zhong)的(de)(de)并發癥(zheng),根據目前抗(kang)(kang)感(gan)染治療的(de)(de)原則,要早期針對(dui)革蘭陰性桿菌(jun)(jun)大劑量、短時間(jian)應用(yong)抗(kang)(kang)菌(jun)(jun)藥(yao)物(wu),并且(qie)注意抗(kang)(kang)厭氧菌(jun)(jun)藥(yao)物(wu)治療。抗(kang)(kang)菌(jun)(jun)藥(yao)物(wu)可選用(yong)氨基苷類如阿米卡星(丁胺(an)卡那(nei)霉(mei)素)、妥布霉(mei)素,或三代頭孢(bao)菌(jun)(jun)素類如先鋒必(bi)素、頭孢(bao)曲(qu)松(菌(jun)(jun)必(bi)治)等(deng),聯用(yong)甲硝(xiao)唑靜脈滴(di)注。
4、營養支持、糾正水電解質代謝紊亂與酸堿平衡失調
對(dui)膽道(dao)感(gan)染者(zhe),全身中毒癥狀(zhuang)嚴重,或(huo)腹痛、嘔(ou)吐頻繁,或(huo)出現其他并發癥者(zhe),應予(yu)以禁(jin)食、輸液(ye)、補充(chong)維生素,維持酸堿平衡。必要時(shi)給予(yu)高熱(re)量液(ye)體、新鮮冰(bing)凍血漿等。
二、手術治療
1、適應證
(1)膽(dan)道蛔蟲病頻繁發作的劇烈絞(jiao)痛(tong),經各種(zhong)非手術治療難以控制,有(you)繼發感染等并發癥發生的危險。
(2)合并膽道(dao)結石(shi),易發生梗阻性化(hua)膿性膽管炎(yan)者。
(3)影像學檢(jian)查發現膽(dan)道多條蛔蟲者。
(4)并(bing)發(fa)肝膿(nong)腫(zhong)、嚴重(zhong)膽道(dao)感(gan)染(ran)、膽道(dao)出血或膽道(dao)穿孔者(zhe)。
(5)并(bing)發急性胰腺炎非(fei)手(shou)術治療無效者。
(6)治療(liao)后急性(xing)期癥狀緩解,但非手(shou)術(shu)治療(liao)后4~6周檢查仍有膽(dan)總管(guan)(guan)擴(kuo)張或(huo)膽(dan)管(guan)(guan)內死蟲殘留者。
2、手術方法
膽(dan)道蛔蟲病無并發癥(zheng)時(shi)可(ke)采用膽(dan)總管(guan)切開(kai)取(qu)蟲及(ji)T管(guan)引流(liu)術,有(you)(you)條(tiao)件時(shi)可(ke)行(xing)術中(zhong)膽(dan)道造影(ying)以免(mian)多(duo)條(tiao)蛔蟲存在(zai)時(shi)漏取(qu)。術后置T管(guan)引流(liu)便于(yu)局部(bu)用藥或沖洗,拔管(guan)前行(xing)造影(ying)檢查如(ru)有(you)(you)殘(can)留蛔蟲再經T管(guan)竇道用膽(dan)道鏡(jing)取(qu)出。如(ru)膽(dan)囊內有(you)(you)蛔蟲時(shi)往(wang)往(wang)需行(xing)膽(dan)囊切33%